HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate → 5,6-dichloro-N-isopropyl-1H-benzo[d]imidazol-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate | HCID 17220 | — |
| Reactant | Isopropyl Isothiocyanate | HCID 75263 | — |
| Reactant | 3,4-Dichlorobenzene-1,2-diamine | HCID 10845020 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5,6-dichloro-N-isopropyl-1H-benzo[d]imidazol-2-amine | HCID 22995418 | 67% |
Reaction Steps
5,6-Dichloro-1,2-phenylenediamine (200.0 g, 1.13 mol), isopropyl isothiocyanate (122.0 g, 1.21 mol), 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate (622.0 g, 1.47 mol) and pyridine (4 L) were used according to general procedure I. The product was recrystallized from acetonitrile to give 184 g (67%) of a brown solid. Analytical data were consistent with those reported above.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06307043B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-2d735844a18a495dae307efce500f729 |
| Source note | uspto-grants-2001_10 |