Ammonia → 1,3,5-Triazine-2,4-diamine, 6-chloro-

Temperature

0 °C

To a solution of 184.5 g (1.0 mol) of cyanuric chloride dissolved in 800 ml of acetonitrile at room temperature and cooled to 0° C., 303.7 g (5.0) of 28% aqueous ammonia solution was added at dropwise over 2 hour with vigorous stirring such that the reaction temperature was maintained below 10° C. After completion of the addition, the cooling was stopped and the mixture was stirred at room temperature for 1 hour and then the temperature was gradually elevated to 45° C. and the reaction was continued for additional 4 hours. After cooling, the product was filtered off and further washed with a large amount of water. The filtrate was dried at 50° C. for 6 hours under vacuum to obtain 115 g (yield: 79%) of the titled compound.

1. temperaturewas maintained below 10° C
2. additionAfter completion of the addition
3. stirringthe mixture was stirred at room temperature for 1 hour
4. customwas gradually elevated to 45° C.
5. temperatureAfter cooling
6. filtrationthe product was filtered off
7. washfurther washed with a large amount of water
8. customThe filtrate was dried at 50° C. for 6 hours under vacuum

ORD record

ord-5ae7f8bbb99044b682c90bb2af40fbf4

Source dataset

uspto-grants-2001_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06307046B1