Bepotastine → Bepotastine Besilate

HRID 381669Notes

Reaction equation

HRID 381669 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH2:12][CH2:11]2)=[CH:4][CH:3]=1.O.[C:29]1([S:35]([OH:38])(=[O:37])=[O:36])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>C(OCC)(=O)C>[C:29]1([S:35]([OH:38])(=[O:37])=[O:36])[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C@@H:8]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH2:12][CH2:11]2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 164522BepotastineHCID 15619088Hydroxybenzenesulfonic acid

Product 1

HCID 164521Bepotastine BesilateYield 67.3%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In 25 ml of ethyl acetate was dissolved 0.5 g (1.29 mmol) of (S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino]butanoic acid obtained according to Example 1, and then, 0.20 g (1.14 mmol) of benzenesulfonic acid monohydrate was added and the mixture was concentrated under reduced pressure. To the residue was added again 25 ml of ethyl acetate and the mixture was allowed to stand for about one week, part of the syrupy product was crystallized. When the material was stirred by a spatula and further allowed to stand, whole parts were crystallized. This crystals were recrystallized from 5 ml of acetonitrile to afford 0.42 g (Yield: 67.3%, optical purity: 99.2% e.e.) of the desired product as pale gray prisms.

Workup

  1. customobtained
  2. concentrationthe mixture was concentrated under reduced pressure
  3. additionTo the residue was added again 25 ml of ethyl acetate
  4. waitto stand for about one week
  5. custompart of the syrupy product was crystallized
  6. customwhole parts were crystallized
  7. customThis crystals were recrystallized from 5 ml of acetonitrile

Sources & evidence

ORD record
ord-6c2f8e4805da481cbcdd2c1da653ad1f
Source dataset
uspto-grants-2001_10
Patent number
US06307052B1

Reaction notes

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