2-((4-Chlorophenyl)(4-piperidinyloxy)methyl)pyridine → 2-((4-Chlorophenyl)(piperidin-4-yloxy)methyl)pyridine, (S)-

HRID 381671Notes

Reaction equation

HRID 381671 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[O:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:4][CH:3]=1.O[C@@H]([C@@H](C1C=CC(OC)=CC=1)SC1C=CC=CC=1[N+]([O-])=O)C(O)=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[O:9][CH:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 111411972-((4-Chlorophenyl)(4-piperidinyloxy)methyl)pyridineHCID 13191817(2R,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)propionic acid

Product 1

HCID 108920052-((4-Chlorophenyl)(piperidin-4-yloxy)methyl)pyridine, (S)-

Procedure

By treating (±)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine and (2R,3R)-2-hydroxy-3-(4-methoxy-phenyl)-3-(2-nitrophenylthio)propionic acid in the same manner as in Example 4-(1), (2) and (3) to afford (S)-4-[(4-chlorophenyl) (2-pyridyl)methoxy]piperidine.

Sources & evidence

ORD record
ord-d3e7310ba2b74530ba97ab5257c82fcb
Source dataset
uspto-grants-2001_10
Patent number
US06307052B1

Reaction notes

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