HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 381681Generated: October 26, 2026
Potassium Carbonate → 4-(4-Chloro-but-2-ynoxy)-2-isopropylidenecoumaran-3-one
https://huagongshe.com/reaction/381681
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,4-Dichloro-2-butyne | HCID 13182 | — |
| Reactant | 4-Hydroxy-2-(propan-2-ylidene)-1-benzofuran-3(2H)-one | HCID 18363836 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(4-Chloro-but-2-ynoxy)-2-isopropylidenecoumaran-3-one | HCID 18363846 | — |
Reaction Steps
A mixture of 5.0 g 4-hydroxy-2-isopropylidenecoumaran-3-one, 4.6 g potassium carbonate, 3.3 ml 1,4-dichloro-but-2-yne and 100 ml dimethylformamide is warmed to 50° C. for 3 hours, then evaporated, mixed with water and extracted with dichloromethane. After evaporation of the extract, the residue (9.2 g) is purified by silica gel chromatography (eluent isohexane/ethyl acetate 9:1) to give 2.2 g of the desired intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06307051B1 |
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| Source dataset | uspto-grants-2001_10 |
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| ORD ID | ord-aad3ab8d25e0497ea51d061d5aeebf55 |
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| Source note | uspto-grants-2001_10 |
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