反应详情

温度

50 °C

A mixture of 5.0 g 4-hydroxy-2-isopropylidenecoumaran-3-one, 4.6 g potassium carbonate, 3.3 ml 1,4-dichloro-but-2-yne and 100 ml dimethylformamide is warmed to 50° C. for 3 hours, then evaporated, mixed with water and extracted with dichloromethane. After evaporation of the extract, the residue (9.2 g) is purified by silica gel chromatography (eluent isohexane/ethyl acetate 9:1) to give 2.2 g of the desired intermediate.

1. customevaporated
2. additionmixed with water
3. extractionextracted with dichloromethane
4. customAfter evaporation of the extract
5. customthe residue (9.2 g) is purified by silica gel chromatography (eluent isohexane/ethyl acetate 9:1)