HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-(4-Chloromethyl-phenylmethoxy)-2-isopropylidenecoumaran-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | alpha,alpha'-Dichloro-p-xylene | HCID 12171 | — |
| Reactant | 4-Hydroxy-2-(propan-2-ylidene)-1-benzofuran-3(2H)-one | HCID 18363836 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 4-(4-Chloromethyl-phenylmethoxy)-2-isopropylidenecoumaran-3-one | HCID 18363838 | 19.8% |
Reaction Steps
2.8 g Potassium carbonate is added over 3 hours to a mixture of 3.8 g 4-hydroxy-2-isopropylidenecoumaran-3-one, 3.5 g 1,4-bis-(chloromethyl)benzene and 150 ml butanone at 70-75° C. The mixture is refluxed for 16 hours, then filtered, the filtrate evaporated and the residue purified by silica gel chromatography (eluent isohexane/ethyl acetate 3:1) to give 1.3 g of the desired intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06307051B1 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-1d37f4c1fabe496b92c3eb3b31ef3485 |
| Source note | uspto-grants-2001_10 |