反应详情

2.8 g Potassium carbonate is added over 3 hours to a mixture of 3.8 g 4-hydroxy-2-isopropylidenecoumaran-3-one, 3.5 g 1,4-bis-(chloromethyl)benzene and 150 ml butanone at 70-75° C. The mixture is refluxed for 16 hours, then filtered, the filtrate evaporated and the residue purified by silica gel chromatography (eluent isohexane/ethyl acetate 3:1) to give 1.3 g of the desired intermediate.

1. temperatureThe mixture is refluxed for 16 hours
2. filtrationfiltered
3. customthe filtrate evaporated
4. customthe residue purified by silica gel chromatography (eluent isohexane/ethyl acetate 3:1)