Potassium Carbonate → HCID 18364049, compound

HRID 381724Notes

Reaction equation

HRID 381724 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[C:8]2[C:4]=1[C:5](=[O:14])[CH2:6][NH:7]2.[C:15]([O-])([O-])=[O:16].[K+].[K+]>CC(C)=O>[CH3:1][O:2][C:3]1[C:11]([O:16][CH3:15])=[C:10]([O:12][CH3:13])[CH:9]=[C:8]2[C:4]=1[C:5](=[O:14])[CH2:6][NH:7]2

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 18364046HCID 18364046, compound

Product 1

HCID 18364049HCID 18364049, compoundYield 21%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Compound (9) was synthesized from (8) in the same manner as described for the synthesis of (6) using 2-amino-4,5,6-trimethoxy-a-chloroacetophenone (1.05 g, 4.0 n-mmol), K2CO3 (838 mg, 6.1 mmol), a little KI, and dry acetone (50 ml). Purification by column chromatography (eluent: CH2Cl2/MeOH: 9/1) afforded (9) (190 mg, 21%) as red crystals.

Workup

  1. customPurification by column chromatography (eluent: CH2Cl2/MeOH: 9/1)

Sources & evidence

ORD record
ord-dcfec54db608482ea4d17be59d762818
Source dataset
uspto-grants-2001_10
Patent number
US06307070B1

Reaction notes

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