反应详情

In a manner similar to that described for Example 4, Step (c), 4-(4′-bromo-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid (1.05 g, 0.00300 mol) was allowed to react with hydroxylamine hydrochloride (0.256 g, 0.00368 mol) to give 1.00 g of 4-(4′-bromo-2′-fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid as a white solid; mp 163-164° C.