HCID 86583516, compound → 4-(2'-Fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acid

HRID 381829Notes

Reaction equation

HRID 381829 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:21])[CH2:15][CH2:16][C:17]([O:19]C)=[O:18])=[CH:10][CH:9]=2)=[C:4]([F:22])[CH:3]=1>Cl>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14](=[O:21])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:13]=2)=[C:4]([F:22])[CH:3]=1

Participants

3

Reactant 1

HCID 86583516HCID 86583516, compound

Product 1

HCID 183641244-(2'-Fluoro-4'-chloro-4-biphenylyl)-4-oxo-butyric acidYield 91.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

In a manner similar to Example 4, Step (b), 4-(4′-chloro-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (1.39 g, 0.00433 mol) was refluxed in 6 M hydrochloric acid to give 1.22 g of 4-(4′-chloro-2′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid as a light purple solid; mp 127-129° C.

Sources & evidence

ORD record
ord-f93d7f0e03df4d8d8cf21ae899784efe
Source dataset
uspto-grants-2001_10
Patent number
US06307089B2

Reaction notes

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