Sodium Carbonate → HCID 73432326, compound

HRID 381840Notes

Reaction equation

HRID 381840 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH:15]([CH2:19][CH:20]=O)C(O)=O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.Cl.[NH2:23][OH:24].[C:25](=[O:28])([O-])[O-:26].[Na+].[Na+]>C(O)C>[OH:24][N:23]=[C:15]([C:12]1[CH:11]=[CH:10][C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[CH:14][CH:13]=1)[CH2:19][CH2:20][C:25]([OH:26])=[O:28]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 18364145HCID 18364145, compound

Product 1

HCID 73432326HCID 73432326, compoundYield 86.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner similar to Example 4, Step (c), (4′-methoxy-biphenyl-4-yl)-4-oxo-butyric acid (1.08 g, 0.00380 mol) was allowed to react with hydroxylamine hydrochloride (0.316 g, 0.00455 mol) in the presence of sodium carbonate (0.485 g, 0.00458 mol) in absolute ethanol (20 mL) to give 0.983 g of 4-hydroxyimino-4-(4′-methoxy-biphenyl-4-yl)-butyric acid as a pale yellow solid; mp 157-160° C.

Sources & evidence

ORD record
ord-da137cfdc56142af94cd760b927329a8
Source dataset
uspto-grants-2001_10
Patent number
US06307089B2

Reaction notes

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