HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid methyl ester → 4-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid methyl ester | HCID 70230255 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid | HCID 23005236 | 96.6% |
Reaction Steps
In a manner similar to Example 4, Step (b), 4-(3′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (1.0968 g, 0.00383 mol) was refluxed in 6 M aqueous hydrochloric acid (20 mL) to give 1.007 g of 4-(3′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid as a pale orange solid; mp 153-155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06307089B2 |
| Source dataset | uspto-grants-2001_10 |
| ORD ID | ord-5b90587b3f0d442a9b07bf2a825424d6 |
| Source note | uspto-grants-2001_10 |