4-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid methyl ester → 4-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid

HRID 381846Notes

Reaction equation

HRID 381846 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:21])[CH2:15][CH2:16][C:17]([O:19]C)=[O:18])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1>Cl>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:21])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 702302554-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid methyl ester

Product 1

HCID 230052364-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acidYield 96.6%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

In a manner similar to Example 4, Step (b), 4-(3′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (1.0968 g, 0.00383 mol) was refluxed in 6 M aqueous hydrochloric acid (20 mL) to give 1.007 g of 4-(3′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid as a pale orange solid; mp 153-155° C.

Sources & evidence

ORD record
ord-5b90587b3f0d442a9b07bf2a825424d6
Source dataset
uspto-grants-2001_10
Patent number
US06307089B2

Reaction notes

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