Sodium Carbonate → 4-(3'-Fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid

HRID 381847Notes

Reaction equation

HRID 381847 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=O)[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl.[NH2:22][OH:23].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[N:22][OH:23])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 230052364-(3'-Fluoro-biphenyl-4-yl)-4-oxo-butyric acid

Product 1

HCID 734323204-(3'-Fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a manner similar to Example 4, Step (c), 4-(3′-fluoro-biphenyl-4-yl)-4-oxo-butyric acid (0.9258 g, 0.00340 mol) was allowed to react with hydroxylamine hydrochloride (0.284 g, 0.00409 mol) in the presence of sodium carbonate (0.434 g, 0.00409 mol) in absolute ethanol (19 mL) to give 4-(3′-fluoro-biphenyl-4-yl)-4-hydroxyimino-butyric acid as a pale gray solid; mp 155-157° C.

Sources & evidence

ORD record
ord-a8bcc4d527dd48a297eb273b65390dd1
Source dataset
uspto-grants-2001_10
Patent number
US06307089B2

Reaction notes

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