Hydrogen Bromide → HCID 54689952, compound

HRID 381866Notes

Reaction equation

[C:1]1([N:7]2[C:12](=[O:13])[C:11]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)=[C:10]([O:21]C)[CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br>>[C:1]1([N:7]2[C:12](=[O:13])[C:11]([C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)=[C:10]([OH:21])[CH:9]=[N:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 219338502-phenyl-4-(4-fluorophenyl)-5-methoxy-3(2H)-pyridazinone

Product 1

HCID 54689952HCID 54689952, compoundYield 92%

Procedure

The 2-phenyl-4-(4-fluorophenyl)-5-methoxy-3(2H)-pyridazinone product was treated with 48% HBr according to the method of Example 7 to furnish 2-phenyl-4-(4-fluorophenyl)-5-hydroxy-3(2H)-pyridazinone (yield: 957 mg, 92%). MS (DCI/NH3) m/z 283 (M+H)+, 300 (M+NH4)+.

Sources & evidence

ORD record: ord-ca07820085c64b6fbcdad1f110bb85d1
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06307047B1

Reaction notes

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