Isobutanol → 2-(3-Chlorophenyl)-4-(2-methylpropoxy)-5-bromo-3(2H)-pyridazinone

HRID 381933Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:13](=[O:14])[C:12](Br)=[C:11]([Br:16])[CH:10]=[N:9]2)[CH:5]=[CH:6][CH:7]=1.[CH3:17][CH:18]([CH3:21])[CH2:19][OH:20]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:13](=[O:14])[C:12]([O:20][CH2:19][CH:18]([CH3:21])[CH3:17])=[C:11]([Br:16])[CH:10]=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6560Isobutanol

HCID 219340284,5-Dibromo-2-(3-chlorophenyl)pyridazin-3(2H)-one

Product 1

HCID 219338642-(3-Chlorophenyl)-4-(2-methylpropoxy)-5-bromo-3(2H)-pyridazinone

Procedure

The title compound was prepared according to the method of Example 194B, starting with 2-(3-chlorophenyl)-4,5-dibromo-3(2H)-pyridazinone (Example 207A) in place of 2-(4-fluorophenyl)-4,5-dibromo-3(2H)-pyridazinone and substituting 2-methyl-1-propanol in place of methanol.

Sources & evidence

ORD record: ord-5651a91e51ce4b13aa23c1743ce2b504
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06307047B1

Reaction notes

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