1H-indazol-3-amine → (1H-Indazol-3-yl)-[3-(2-trifluoromethyl-phenyl)-isoquinoline-1-yl]-amine

HRID 38195Notes

Reaction equation

HRID 38195 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[C:18]([F:21])([F:20])[F:19])[N:3]=1.[NH:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24]([NH2:31])=[N:23]1>C(O)C>[NH:22]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[C:24]([NH:31][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH:5]=[C:4]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=3[C:18]([F:21])([F:20])[F:19])[N:3]=2)=[N:23]1

Participants

4

Reactant 2

HCID 133991H-indazol-3-amineHCID 219392261-Chloro-3-(2-trifluoromethyl-phenyl)-isoquinoline

Product 1

HCID 10179350(1H-Indazol-3-yl)-[3-(2-trifluoromethyl-phenyl)-isoquinoline-1-yl]-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 1-chloro-3-(2-trifluoromethyl-phenyl)-isoquinoline (100 mg, 0.326 mmol) and 1H-indazol-3-ylamine (86 mg, 0.651 mmol) in ethanol (3 mL) was heated at 160 C and the solvent evaporated with a stream of nitrogen. The remaining oil was then heated at 160 C for 18 hours under nitrogen.

Workup

  1. customthe solvent evaporated with a stream of nitrogen
  2. temperatureThe remaining oil was then heated at 160 C for 18 hours under nitrogen

Sources & evidence

ORD record
ord-991c17f5943147f784592b3b5b309c8b
Source dataset
uspto-grants-2013_09
Patent number
US08524720B2

Reaction notes

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