HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-indazol-3-amine → (1H-Indazol-3-yl)-[3-(2-trifluoromethyl-phenyl)-isoquinoline-1-yl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-indazol-3-amine | HCID 13399 | — |
| Reactant | 1-Chloro-3-(2-trifluoromethyl-phenyl)-isoquinoline | HCID 21939226 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (1H-Indazol-3-yl)-[3-(2-trifluoromethyl-phenyl)-isoquinoline-1-yl]-amine | HCID 10179350 | — |
Reaction Steps
A solution of 1-chloro-3-(2-trifluoromethyl-phenyl)-isoquinoline (100 mg, 0.326 mmol) and 1H-indazol-3-ylamine (86 mg, 0.651 mmol) in ethanol (3 mL) was heated at 160 C and the solvent evaporated with a stream of nitrogen. The remaining oil was then heated at 160 C for 18 hours under nitrogen.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524720B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-991c17f5943147f784592b3b5b309c8b |
| Source note | uspto-grants-2013_09 |