反应详情

To a stirred, room temperature solution of ethyl (R)-3-hydroxybutanoate (5.00 g, 37.8 mmol) and tert-butyldimethylsilyl chloride (6.85 g, 45.5 mmol) in DMF (90 mL) was added imidazole (3.87 g, 56.9 mmol). This reaction mixture was stirred at room temperature for 18 hours. The reaction mixture was partitioned between hexane (300 mL) and water (100 mL). The organic layer was washed with water (2×100 mL) then dried (MgSO4) and filtered. The filtrate was concentrated under reduced pressure to give the title compound.

1. customThe reaction mixture was partitioned between hexane (300 mL) and water (100 mL)
2. washThe organic layer was washed with water (2×100 mL)
3. dry with materialthen dried (MgSO4)
4. filtrationfiltered
5. concentrationThe filtrate was concentrated under reduced pressure