HRID382048

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10340

Carbonic acid sodium salt (1:2)

CNa2O3

HCID2734360

4-Hydroxyphenylboronic acid

C6H7BO3

$结构：COc1cc[nH]c1/C=C1\C(=O)Nc2ccc([N+](=O)[O-])c(Br)c21$

HCID18359293

未命名化合物

2 次

PRODUCTS

生成物

$结构：COc1cc[nH]c1/C=C1\C(=O)Nc2ccc([N+](=O)[O-])c(-c3ccc(O)cc3)c21$

HCID9951621

未命名化合物

收率 52%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8071

未命名化合物

PROCEDURE

实验过程

Using Method S above, 4-hydroxyphenyl boronic acid (85.0 mg, 0.62 mmol) (see Gilman, supra) was coupled with (Z)-4-bromo-1,3-dihydro-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-5-nitro-2H-indol-2-one (150 mg, 0.41 mmol) (Starting Material 6) using DPPFPdCl2 (17 mg) (Aldrich) as catalyst in aqueous 2M Na2CO3 (0.42 mL, 0.84 mmol) and DME (15 mL) at reflux for 1 day to give (Z)-1,3-dihydro-4-(4-hydroxyphenyl)-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-5-nitro-2H-indol-2-one (yield: 11 0 mg, 52%).

WORKUP

后处理

temperatureat reflux for 1 day