Potassium Phosphate, Tribasic → 1-(2'-Methoxy[1,1'-biphenyl]-2-yl)ethanone

Temperature

65 °C

An oven dried resealable Schlenk tube was evacuated and backfilled with argon and charged with palladium acetate (2.2 mg, 0.01 mmol, 1.0 mol %), 2-(di-tert-butylphosphino)biphenyl (6.0 mg, 0.020 mmol, 2.0 mol %), 2-methoxyphenylboronic acid (228 mg, 1.5 mmol), and potassium phosphate (425 mg, 2.0 mmol). The tube was evacuated and backfilled with argon, and toluene (3 mL) and 2′-chloroacetophenone (0.13 mL, 1.0 mmol) were added through a rubber septum. The tube was sealed with a teflon screwcap, and the reaction mixture was heated to 65° C. with stirring until the starting aryl chloride had been completely consumed as judged by GC analysis. The reaction mixture was then diluted with ether (30 mL) and poured into a separatory funnel. The mixture was washed with water (20 mL), and the aqueous layer was extracted with ether (20 mL). The combined organic layers were washed with brine (20 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated. The crude material was purified by flash chromatography on silica gel to afford 201 mg (89%) of the title compound.

1. customAn oven dried resealable Schlenk tube
2. customwas evacuated
3. customThe tube was evacuated
4. additionwere added through a rubber septum
5. customhad been completely consumed
6. additionThe reaction mixture was then diluted with ether (30 mL)
7. additionpoured into a separatory funnel
8. washThe mixture was washed with water (20 mL)
9. extractionthe aqueous layer was extracted with ether (20 mL)
10. washThe combined organic layers were washed with brine (20 mL)
11. dry with materialdried over anhydrous magnesium sulfate
12. filtrationfiltered
13. concentrationconcentrated
14. customThe crude material was purified by flash chromatography on silica gel

ORD record

ord-c6c50fa64d4e4dc3ad91b6565f6ba4f3

Source dataset

uspto-grants-2001_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06307087B1