反应详情

493 mg (2.03 mmol) (RS)—S-(4-aminophenyl)-N-(2-methoxy-acetyl)-S-methylsulphoximide is dissolved in 67.8 ml tetrahydrofuran, cooled in the ice-bath and treated dropwise with 6.13 ml (6.13 mmol) borane tetrahydrofuran complex. The mixture is stirred for 90 minutes and quenched with one drop of methanol and one drop of water. After chromatographic purification (silica gel, hexane/ethyl acetate (0-50% ethyl acetate)), 383 mg (82%) of the desired product is obtained.

1. additiontreated dropwise with 6.13 ml (6.13 mmol) borane tetrahydrofuran complex
2. customquenched with one drop of methanol and one drop of water
3. customAfter chromatographic purification (silica gel, hexane/ethyl acetate (0-50% ethyl acetate))