HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Amino-1-propanol → 3-(2-Chloro-5-iodopyrimidine-4-ylamino)propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Amino-1-propanol | HCID 9086 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,4-Dichloro-5-iodopyrimidine | HCID 263438 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(2-Chloro-5-iodopyrimidine-4-ylamino)propan-1-ol | HCID 59550848 | 95% |
Reaction Steps
In analogy to GP 2 reaction of 3-amino-1-propanol (0.38 ml, 5 mmol) in the presence of N-ethyldiisopropylamine (1.74 ml, 10 mmol) in 150 ml acetonitrile with 2,4-dichloro-5-iodo-pyrimidine (1.51, 5.5 mmol) provided the target compound after column chromatography in 95% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08524724B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-b0321a79913e4845ac3ab8396016247a |
| Source note | uspto-grants-2013_09 |