3-Amino-1-propanol → 3-(2-Chloro-5-iodopyrimidine-4-ylamino)propan-1-ol

HRID 38216Notes

Reaction equation

HRID 38216 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].C(N(C(C)C)C(C)C)C.[Cl:15][C:16]1[N:21]=[C:20](Cl)[C:19]([I:23])=[CH:18][N:17]=1>C(#N)C>[Cl:15][C:16]1[N:21]=[C:20]([NH:1][CH2:2][CH2:3][CH2:4][OH:5])[C:19]([I:23])=[CH:18][N:17]=1

Participants

5

Reactant 3

HCID 90863-Amino-1-propanolHCID 81531DiisopropylethylamineHCID 2634382,4-Dichloro-5-iodopyrimidine

Product 1

HCID 595508483-(2-Chloro-5-iodopyrimidine-4-ylamino)propan-1-olYield 95%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In analogy to GP 2 reaction of 3-amino-1-propanol (0.38 ml, 5 mmol) in the presence of N-ethyldiisopropylamine (1.74 ml, 10 mmol) in 150 ml acetonitrile with 2,4-dichloro-5-iodo-pyrimidine (1.51, 5.5 mmol) provided the target compound after column chromatography in 95% yield.

Workup

  1. customprovided the target compound after column chromatography in 95% yield

Sources & evidence

ORD record
ord-b0321a79913e4845ac3ab8396016247a
Source dataset
uspto-grants-2013_09
Patent number
US08524724B2

Reaction notes

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