Hydrazine hydrate (1:1) → HCID 70020660, compound

HRID 382260Notes

Reaction equation

HRID 382260 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH:9]=[CH:10][C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)=[CH:4][CH:3]=1.O.[NH2:18][NH2:19]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:18][NH:19][CH:10]([C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)[CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 30979891-(4-bromophenyl)-3-(2-thienyl)-2-propen-1-one

Product 1

HCID 70020660HCID 70020660, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-(4-Bromophenyl)-3-(2-thienyl)-2-propen-1-one (3.0 g, 10.2 mmol) and hydrazine hydrate (1.0 g, 20 mmol) were added to ethanol (30 ml) and heated under reflux for 3 hours. After the mixture was allowed to cool to room temperature, the solvent was distilled off to obtain 3.0 g (98%) of the desired 3-(4-bromophenyl)-5-(2-thienyl)-pyrazoline in the form of a resinous material.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 3 hours
  3. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-4e930e5dba444dff9fd9106338b9e3eb
Source dataset
uspto-grants-2001_10
Patent number
US06310049B1

Reaction notes

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