Hydrazine hydrate (1:1) → HCID 70020195, compound

HRID 382261Notes

Reaction equation

HRID 382261 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=O)=[CH:4][CH:3]=1.O.[NH2:18][NH2:19]>C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[NH:19][NH:18][C:10]([C:12]3[S:13][CH:14]=[CH:15][CH:16]=3)=[CH:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 3666021HCID 3666021, compound

Product 1

HCID 70020195HCID 70020195, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-(4-Fluorophenyl)-1-(2-thienyl)-2-propen-1-one (3.5 g, 15 mM) and hydrazine hydrate (1.5 g, 30 mM) were added to ethanol (30 ml) and heated under reflux for 3 hours. After the mixture was allowed to cool to room temperature, the solvent was distilled off to obtain 3.6 g (98%) of the desired 5-(4-fluorophenyl)-3-(2-thienyl)-pyrazoline in the form of a pale-yellow oil, nD20=1.6364.

Workup

  1. temperatureheated
  2. temperatureunder reflux for 3 hours
  3. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-d0ab09aa69d24b8bac46f6ef05359c59
Source dataset
uspto-grants-2001_10
Patent number
US06310049B1

Reaction notes

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