Sodium hydride → HCID 21960155, compound

HRID 382275Notes

Reaction equation

HRID 382275 reaction equation
[CH2:1]([C:3]1[NH:4][C:5](=[O:12])[C:6]([CH2:10][CH3:11])=[C:7]([CH3:9])[N:8]=1)[CH3:2].Br[CH2:14][CH2:15][O:16][C:17]1[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][CH:18]=1.[H-].[Na+]>>[CH2:1]([C:3]1[N:4]([CH2:14][CH2:15][O:16][C:17]2[CH:24]=[CH:23][C:20]([CH:21]=[O:22])=[CH:19][CH:18]=2)[C:5](=[O:12])[C:6]([CH2:10][CH3:11])=[C:7]([CH3:9])[N:8]=1)[CH3:2]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 2627064-(2-Bromoethoxy)BenzaldehydeHCID 135744174HCID 135744174, compound

Product 1

HCID 21960155HCID 21960155, compoundYield 28%

Procedure

The title compound (1.42 g, 28%) was prepared from 2,5-diethyl-4-methyl-1,6-dihydro-6-pyrimidone (2.70 g, 16.26 mmol) and 4-[2-bromoethoxy]benzaldehyde (4.09 g, 17.86 mmol) in the presence of 95% NaH (508 mg, 20 mmol) as base by a similar procedure to that described in preparation 1.

Workup

  1. customthat described in preparation 1

Sources & evidence

ORD record
ord-6ebb49513dd34772bc064adc211ad651
Source dataset
uspto-grants-2001_10
Patent number
US06310069B1

Reaction notes

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