Potassium Carbonate → 4-[2-[4-Oxo-3,4-dihydro-3-quinazolinyl]ethoxy]benzaldehyde

HRID 382277Notes

Reaction equation

HRID 382277 reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][NH:3]1.Br[CH2:13][CH2:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1.C([O-])([O-])=O.[K+].[K+]>>[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]1[CH2:13][CH2:14][O:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 2627064-(2-Bromoethoxy)BenzaldehydeHCID 1354087534(1H)-Quinazolinone

Product 1

HCID 219601684-[2-[4-Oxo-3,4-dihydro-3-quinazolinyl]ethoxy]benzaldehydeYield 73%

Procedure

The title compound (1.5 g 73%) was prepared from 4-oxo-3,4-dihydroquinazoline (1.03 g, 7.05 mmol) and 4-[2-bromoethoxy]benzaldehyde (1.77 g, 7.7 mmol) in the presence of K2CO3 (2.0 g, 14.5 mmol) as base, by a similar procedure to that described in preparation 1.

Workup

  1. customthat described in preparation 1

Sources & evidence

ORD record
ord-dc9f920017fa49a683624c378f0987a1
Source dataset
uspto-grants-2001_10
Patent number
US06310069B1

Reaction notes

Loading…