HCID 25204926, compound → HCID 178434539, compound

HRID 38229Notes

Reaction equation

HRID 38229 reaction equation
COC1C=CC(C[N:8]2[CH:12]=[C:11]([C:13]3[N:17]=[C:16]([NH:18][C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=4)[S:15][N:14]=3)[C:10]([CH3:25])=[N:9]2)=CC=1.COC1C=CC(CN2C(C)=C(C(=N)N)C=N2)=CC=1>>[CH3:25][C:10]1[C:11]([C:13]2[N:17]=[C:16]([NH:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=3)[S:15][N:14]=2)=[CH:12][NH:8][N:9]=1

Participants

3

Reactant 2

HCID 25204926HCID 25204926, compoundHCID 686110331-(4-methoxybenzyl)-5-methyl-1H-pyrazole-4-carboximidamide

Product 1

HCID 178434539HCID 178434539, compoundYield 37%

Procedure

According to Scheme 1 Step 4: The title compound was prepared according to Example 2 Step 4, from a mixture of 3-(1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-4-yl)-N-(pyridin-2-yl)-1,2,4-thiadiazol-5-amine and of 1-(4-methoxybenzyl)-5-methyl-1H-pyrazole-4-carboximidamide (0.11 mmol, 43 mg). 11 mg (43 μmol, 37%) of 3-(3-methyl-1H-pyrazol-4-yl)-N-(pyridin-2-yl)-1,2,4-thiadiazol-5-amine were obtained as a white solid.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-ccb75ca653f84c618805f7c91067e8e2
Source dataset
uspto-grants-2013_09
Patent number
US08524718B2

Reaction notes

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