反应详情

To a stirred solution of (R)-1-benzyl-3-pyrrolidinol (1.77 g, 10 mmol) in pyridine (30 ml) was added p-toluenesulfonyl chloride (9.53 g, 50 mmol) by portions a, 0° C. After 90 h stirring it room temperature, water was added to the reaction mixture and the mixture was extracted with ether (150 ml). The extract was washed with water brine, dried (Na2SO4), and concentrated to give 3.06 g (92%) of brown oil.

1. additionwas added to the reaction mixture
2. extractionthe mixture was extracted with ether (150 ml)
3. washThe extract was washed with water brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated