Carbon tetrabromide → HCID 18360645, compound

HRID 382328Notes

Reaction equation

HRID 382328 reaction equation
O[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[C:10]2[CH2:16][CH2:17][NH:18][C:19](=[O:21])[CH3:20].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Br)(Br)(Br)[Br:42]>C(#N)C>[Br:42][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][CH:11]=[C:10]2[CH2:16][CH2:17][NH:18][C:19](=[O:21])[CH3:20]

Participants

5

Reactant 3

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 18360725HCID 18360725, compound

Product 1

HCID 18360645HCID 18360645, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3.92 g of the compound obtained in Step B are dissolved in 50 ml of acetonitrile, and then 5.31 g of triphenylphosphine and 6.71 g of carbon tetrabromide are added with stirring. After leaving at room temperature overnight, the acetonitrile is removed by evaporation in vacuo and the resulting residue is purified by chromatography over a column of silica gel (eluant: dichloromethane/methanol 96/4). Oil.

Workup

  1. customAfter leaving at room temperature overnight
  2. customthe acetonitrile is removed by evaporation in vacuo
  3. customthe resulting residue is purified by chromatography over a column of silica gel (eluant: dichloromethane/methanol 96/4)

Sources & evidence

ORD record
ord-06d0e912d4e34ade94422ab9a7ea7ea8
Source dataset
uspto-grants-2001_10
Patent number
US06310074B1

Reaction notes

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