反应详情

温度

0 °C

16.3 g (100 mmol) of 4-amino-5-imidazolecarboxamide hydrochloride was suspended in 200 ml ethanol, and 27.8 ml (200 mmol) of triethylamine was added to the suspension and dissolved. To the solution, 10.2 ml (100 mmol) of benzaldehyde was added and the mixture was heated for 8 hours while refluxing. After the addition of 400 ml of distilled water, the reaction mixture was stirred for one hour at 0° C. A solid precipitate produced was collected by filtration, washed with distilled water, then with ethanol, and dried under reduced pressure to obtain 20.8 g of the title compound (yield 97%).

1. dissolutiondissolved
2. temperaturethe mixture was heated for 8 hours
3. temperaturewhile refluxing
4. customA solid precipitate produced
5. filtrationwas collected by filtration
6. washwashed with distilled water
7. dry with materialwith ethanol, and dried under reduced pressure