HCID 135708923, compound → HCID 135708849, compound

HRID 382390Notes

Reaction equation

HRID 382390 reaction equation
C([O:8][C:9]1[C:27]([C:28]([CH3:31])([CH3:30])[CH3:29])=[CH:26][C:12]([CH2:13][N:14]2[C:22]3[C:21](=[O:23])[NH:20][C:19]([CH2:24][CH3:25])=[N:18][C:17]=3[N:16]=[CH:15]2)=[CH:11][C:10]=1[C:32]([CH3:35])([CH3:34])[CH3:33])C1C=CC=CC=1.[H][H]>CO.[C].[Pd]>[CH2:24]([C:19]1[NH:20][C:21](=[O:23])[C:22]2[N:14]([CH2:13][C:12]3[CH:26]=[C:27]([C:28]([CH3:29])([CH3:31])[CH3:30])[C:9]([OH:8])=[C:10]([C:32]([CH3:35])([CH3:34])[CH3:33])[CH:11]=3)[CH:15]=[N:16][C:17]=2[N:18]=1)[CH3:25]

Participants

5

Reactant 2

HCID 135708923HCID 135708923, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 135708849HCID 135708849, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

0.2 g of 10% palladium carbon was added to a solution of 0.9 g (1.90 mmol) of the resulting hypoxanthine compound in 50 ml of methanol and the mixture was stirred overnight in a hydrogen atmosphere. Palladium carbon was removed by filtration and the residue was concentrated under vacuum to obtain 0.64 g of 2-ethyl-7-(4-hydroxy-3,5-di-t-butylbenzyl)hypoxanthine (yield 100%).

Workup

  1. customPalladium carbon was removed by filtration
  2. concentrationthe residue was concentrated under vacuum

Sources & evidence

ORD record
ord-d729c356fe454dfaa73f047bc3dd9c8a
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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