Benzoyl chloride → HCID 18360158, compound

HRID 382394Notes

Reaction equation

HRID 382394 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:17][C:18]([F:29])([F:28])[C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][CH:27]=1)[C:22](Cl)=[O:23].C(Cl)(=O)C1C=CC=CC=1>>[CH2:10]([N:5]1[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:22](=[O:23])[C:21]2[CH:25]=[CH:26][CH:27]=[C:19]([C:18]([F:17])([F:28])[F:29])[CH:20]=2)[N:3]=[CH:4]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 140006201-benzyl-4-amino-1H-imidazole-5-carboxamide

Product 1

HCID 18360158HCID 18360158, compoundYield 92%

Procedure

out under the same conditions as in Example 1, using 2.16 g (9.99 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide which was prepared in the same manner as in Reference Example 2 and 3-trifluoromethylbenzoyl chloride, instead of benzoyl chloride, to obtain 3.56 g 1-benzyl-4-(3-trifluoromethylbenzoylamino)-5-imidazolecarboxamide (yield 92%).

Sources & evidence

ORD record
ord-fc12c323892d4d0f896941d5959bea00
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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