Nicotinic Acid → HCID 18360567, compound

HRID 382399Notes

Reaction equation

HRID 382399 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:18](O)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1>>[F:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:18]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[O:25])[N:3]=[CH:4]2)=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 18360275HCID 18360275, compound

Product 1

HCID 18360567HCID 18360567, compoundYield 79%

Procedure

An amidation reaction and post-treatment were carried out under the same conditions as in Example 19, using 1.50 g (6.38 mmol) of 4-amino-1-(4-fluorobenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 58 and nicotinic acid instead of cyclopentylacetic acid to obtain 1.70 g of 1-(4-fluorobenzyl)-4-(3-pyridylcarbonylamino)-5-imidazolecarboxamide (yield 79%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-bd860dd0b9da4598b8f299cea8dbc843
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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