Nicotinic Acid → HCID 18360507, compound

HRID 382400Notes

Reaction equation

HRID 382400 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:18](O)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1>>[Cl:17][C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][CH:14]=1)[CH2:10][N:5]1[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:18]([C:19]2[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=2)=[O:25])[N:3]=[CH:4]1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 18360350HCID 18360350, compound

Product 1

HCID 18360507HCID 18360507, compoundYield 78%

Procedure

An amidation reaction and post-treatment were carried out under the same conditions as in Example 19, using 1.50 g (5.98 mmol) of 4-amino-1-(3-chlorobenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 51 and nicotinic acid instead of cyclopentylacetic acid to obtain 1.65 g of 1-(3-chlorobenzyl)-4-(3-pyridylcarbonylamino)-5-imidazolecarboxamide (yield 78%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-85aa6b82f08842678c3504f5c406c375
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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