2-Fluorobenzoyl chloride → HCID 18360329, compound

HRID 382403Notes

Reaction equation

HRID 382403 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22](Cl)=[O:23]>>[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:23]

Participants

3

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 18360238HCID 18360238, compound

Product 1

HCID 18360329HCID 18360329, compoundYield 82%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 1, using 1.97 g (8.00 mmol) of 4-amino-1-(3-methoxybenzyl)-5-imidazolecarboxamide prepared in the same manner as in Example 81 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain 2.42 g of 4-(2-fluorobenzoylamino)-1-(3-methoxybenzyl)-5-imidazole carboxamide (yield 82%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-147dca93715c434baf732c1abf124137
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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