Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl- → HCID 18360169, compound

HRID 382405Notes

Reaction equation

HRID 382405 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:19]([O:23][C:24]([N:26]([CH2:28][C:29](O)=[O:30])[CH3:27])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24]([N:26]([CH2:28][C:29]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:30])[CH3:27])=[O:25])([CH3:22])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 83692Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-HCID 18360238HCID 18360238, compound

Product 1

HCID 18360169HCID 18360169, compoundYield 63%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 17, using 1.97 g (8.00 mmol) of 4-amino-1-(3-methoxybenzyl)-5-imidazolecarboxamide prepared in the same manner as in Example 81 and 2-(N-t-butyloxycarbonyl-N-methylamino)acetic acid instead of 3-pyridylacetic acid hydrochloride to obtain 2.12 g of 4-(2-(N-t-butyloxycarbonyl-N-methylamino)acetylamino)-1-(3-methoxybenzyl)-5-imidazolecarboxamide (yield 63%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-c53b917a127a4b6283b1da62d5907c6e
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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