Nicotinic Acid → HCID 18360418, compound

HRID 382410Notes

Reaction equation

HRID 382410 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:18](O)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1>>[C:12]1([CH2:11][CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:18]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[O:25])[N:3]=[CH:4]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 938Nicotinic AcidHCID 18360432HCID 18360432, compound

Product 1

HCID 18360418HCID 18360418, compound

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 17, using 2.00 g (8.69 mmol) of 4-amino-1-(2-phenylethyl)-5-imidazolecarboxamide prepared in the same manner as in Example 56 and nicotinic acid instead of 3-pyridylacetic acid hydrochloride to obtain crude 1-(2-phenylethyl)-4-(3-pyridylcarbonylamino)-5-imidazolecarboxamide.

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-d7e6a73893c642d0b6f860b088a3d58a
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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