2-Thiophenecarboxylic acid → HCID 18360530, compound

HRID 382414Notes

Reaction equation

HRID 382414 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[C:22](O)=[O:23]>>[CH2:10]([N:5]1[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:22]([C:18]2[S:17][CH:21]=[CH:20][CH:19]=2)=[O:23])[N:3]=[CH:4]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 107002-Thiophenecarboxylic acidHCID 140006201-benzyl-4-amino-1H-imidazole-5-carboxamide

Product 1

HCID 18360530HCID 18360530, compoundYield 60%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 17, using 2.14 g (9.99 mmol) of 4-amino-1-benzyl-5-imidazolecarboxamide prepared in the same manner as in Reference Example 2 and 2-thiophenecarboxylic acid instead of 3-pyridylacetic acid hydrochloride to obtain 1.97 g of 1-benzyl-4-(2-thienylcarbonylamino)-5-imidazolecarboxamide (yield 60%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-912513d0973b49d18120b336c9aabcc3
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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