3-(Trifluoromethyl)benzoyl chloride → HCID 18360439, compound

HRID 382417Notes

Reaction equation

HRID 382417 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:21][C:22]([F:33])([F:32])[C:23]1[CH:24]=[C:25]([CH:29]=[CH:30][CH:31]=1)[C:26](Cl)=[O:27]>>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:26](=[O:27])[C:25]3[CH:29]=[CH:30][CH:31]=[C:23]([C:22]([F:21])([F:32])[F:33])[CH:24]=3)[N:3]=[CH:4]2)=[CH:12][CH:13]=1)([CH3:20])([CH3:19])[CH3:18]

Participants

3

Reactant 2

HCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 183602894-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide

Product 1

HCID 18360439HCID 18360439, compoundYield 70%

Procedure

An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 1.91 g (7.01 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 57 and 3-trifluoromethylbenzoyl chloride instead of benzoyl chloride to obtain 2.17 g of 1-(4-t-butylbenzyl)-4-(3-trifluoromethylbenzoylamino)-5-imidazolecarboxamide (yield 70%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-e4bb2144751d40f7bf3864867f3a88c6
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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