3-(Trifluoromethyl)benzoyl chloride → HCID 18360439, compound

Participants

Reaction Steps

An amidation reaction and post-treatment were carried out under the same conditions as in Example 1, using 1.91 g (7.01 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 57 and 3-trifluoromethylbenzoyl chloride instead of benzoyl chloride to obtain 2.17 g of 1-(4-t-butylbenzyl)-4-(3-trifluoromethylbenzoylamino)-5-imidazolecarboxamide (yield 70%).

Provenance & Evidence