2-Fluorobenzoyl chloride → HCID 18360382, compound

HRID 382418Notes

Reaction equation

HRID 382418 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[C:6]=1[C:7]([NH2:9])=[O:8].[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21](Cl)=[O:22]>>[F:18][C:19]1[CH:27]=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[C:6]=1[C:7]([NH2:9])=[O:8])=[O:22]

Participants

3

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 18360259HCID 18360259, compound

Product 1

HCID 18360382HCID 18360382, compoundYield 97%

Procedure

An amidation reaction and post-treatment were carried out under the same conditions as in Example 22, using 1.50 g (6.40 mol) of 4-amino-1-(2-fluorobenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 113 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain 2.21 g of 4-(2-fluorobenzoylamino)-1-(2-fluorobenzyl)-5-imidazolecarboxamide (yield 97%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-8be7f5bb463c4480b20c58c0a4252741
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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