3-Fluorobenzoyl chloride → HCID 18360380, compound

HRID 382423Notes

Reaction equation

HRID 382423 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][CH:27]=1)[C:22](Cl)=[O:23]>>[F:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][CH:27]=1)[C:22]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:23]

Participants

3

Reactant 2

HCID 743763-Fluorobenzoyl chlorideHCID 183605694-Amino-1-(4-methylbenzyl)-5-imidazolecarboxamide

Product 1

HCID 18360380HCID 18360380, compoundYield 88%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 1, using 2.30 g (9.99 mmol) of 4-amino-1-(4-methylbenzyl)-5-imidazolecarboxamide prepared in the same manner as in Example 87 and 3-fluorobenzoyl chloride instead of benzoyl chloride to obtain 3.11 g of 4-(3-fluorobenzoylamino)-1-(4-methylbenzyl)-5-imidazole carboxamide (yield 88%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-68153e3e9d2b4a2db5a51af0917b2a13
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

Loading…