4-Fluorobenzoyl chloride → HCID 18360516, compound

HRID 382424Notes

Reaction equation

HRID 382424 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:1][C:2]2[N:3]=[CH:4][N:5]([CH2:10][C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)[C:6]=2[C:7]([NH2:9])=[O:8])=[O:24])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 183605694-Amino-1-(4-methylbenzyl)-5-imidazolecarboxamide

Product 1

HCID 18360516HCID 18360516, compoundYield 64%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 1, using 2.30 g (9.99 mmol) of 4-amino-1-(4-methylbenzyl)-5-imidazolecarboxamide prepared in the same manner as in Example 87 and 4-fluorobenzoyl chloride instead of benzoyl chloride to obtain 2.26 g of 4-(4-fluorobenzoylamino)-1-(4-methylbenzyl)-5-imidazole carboxamide (yield 64%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-929fea50df074edba5bb553f6f457733
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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