4-Fluorobenzoyl chloride → HCID 18360369, compound

HRID 382426Notes

Reaction equation

HRID 382426 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>>[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([NH:1][C:2]2[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[C:7]([NH2:9])=[O:8])=[O:25])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 18360337HCID 18360337, compound

Product 1

HCID 18360369HCID 18360369, compoundYield 93%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 22, using 2.00 g (8.19 mmol) of 4-amino-1-(3-phenylpropyl)-5-imidazolecarboxamide prepared in the same manner as in Example 114 and 4-fluorobenzoyl chloride instead of benzoyl chloride to obtain 2.78 g of 4-(4-fluorobenzoylamino)-1-(3-phenylpropyl)-5-imidazolecarboxamide (yield 93%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-0a7e0dc571554e5fa12194785bec6cfb
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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