2-Fluorobenzoyl chloride → HCID 18360413, compound

HRID 382435Notes

Reaction equation

HRID 382435 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22](Cl)=[O:23]>>[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=1[C:22]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:23]

Participants

3

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 18360315HCID 18360315, compound

Product 1

HCID 18360413HCID 18360413, compoundYield 93%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 22, using 1.00 g (4.06 mmol) of 4-amino-1-(2-phenoxyethyl)-5-imidazolecarboxamide prepared in the same manner as in Example 155 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain 1.39 g of 4-(2-fluorobenzoylamino)-1-(2-phenoxyethyl)-5-imidazolecarboxamide (yield 93%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-8f5342852605490788ae61d3a7219edd
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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