2-Fluorobenzoyl chloride → HCID 18360564, compound

HRID 382436Notes

Reaction equation

HRID 382436 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[F:20][C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23](Cl)=[O:24]>>[F:20][C:21]1[CH:29]=[CH:28][CH:27]=[CH:26][C:22]=1[C:23]([NH:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:6]=1[C:7]([NH2:9])=[O:8])=[O:24]

Participants

3

Reactant 2

HCID 98082-Fluorobenzoyl chlorideHCID 18360555HCID 18360555, compound

Product 1

HCID 18360564HCID 18360564, compoundYield 92%

Procedure

An amidation reaction and post-treatment were carried out following the conditions of Example 22, using 1.00 g (3.84 mmol) of 4-amino-1-(3-phenoxypropyl)-5-imidazolecarboxamide prepared in the same manner as in Example 156 and 2-fluorobenzoyl chloride instead of benzoyl chloride to obtain 1.35 g of 4-(2-fluorobenzoylamino)-1-(3-phenoxypropyl)-5-imidazolecarboxamide (yield 92%).

Workup

  1. customAn amidation reaction

Sources & evidence

ORD record
ord-3cd3bbf9e84c4f099d4c5b4fc2c0939c
Source dataset
uspto-grants-2001_10
Patent number
US06310070B1

Reaction notes

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