4-Methoxybenzenethiol → alpha-[2-(4-Methoxyphenylthio)5-furyl]-N-n-propylnitrone

HRID 382449Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([SH:9])=[CH:5][CH:4]=1.[CH2:10]([NH:13][OH:14])[CH2:11][CH3:12]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:3]2[O:2][C:11]([CH:10]=[N+:13]([CH2:5][CH2:6][CH3:7])[O-:14])=[CH:12][CH:4]=2)=[CH:5][CH:4]=1

Participants

Reactant 2

HCID 127654-Methoxybenzenethiol

HCID 10148984N-propylhydroxylamine

Product 1

HCID 73433665alpha-[2-(4-Methoxyphenylthio)5-furyl]-N-n-propylnitrone

Procedure

The title compound was prepared according to the procedure described in Example 1 using 4-methoxybenzenethiol and N-n-propylhydroxylamine. The title compound was isolated in 76.6% yield as slightly yellowish crystals, m.p. 63.0° C. (Rf=0.17 on a silica gel plate using hexanes/EtOAc, 2:1, v:v, as the eluant).

Workup

customThe title compound was prepared

Sources & evidence

ORD record: ord-d93f40729421425189f637f8831b5ec3
Source dataset: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06310092B1

Reaction notes

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